HCID 18419442, compound → HCID 15887619, compound

Participants

Reaction Conditions

Reaction Steps

Acetic acid 2-(6-(4-chloro-2-methyl-phenoxy)-pyridin-3-ylcarbamoyl)-phenyl ester (304 mg, 0.77 mmol) dissolved in tetrahydrofuran (3.8 mL) was treated with an aqueous lithium hydrozide solution (1.0 M, 3.8 mL, 3.8 mmol). The solution was stirred for 30 minutes at 22° C. then quenched with aqueous saturated NH4Cl. The mixture was diluted with ethyl acetate then the organics were washed with water, 2× saturated NaHCO3, saturated NaCl, dried over Na2SO4 and concentrated in vacuo. MS (m/z): 354/356 (M+H)+; C19H15N2O3Cl requires 354.8.

Provenance & Evidence