化工社化工社 化学情報印刷レポート · 研究参考用
8-Methoxypsoralen → 4-Bromo-9-methoxy-7h-furo[3,2-g]chromen-7-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-Methoxypsoralen | HCID 4114 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Sodium Thiosulfate | HCID 24477 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Bromo-9-methoxy-7h-furo[3,2-g]chromen-7-one | HCID 240048 | 73.5% |
反応手順
8-methoxypsoralen (8-MOP, Aldrich, Milwaukee, Wis., 0.75 g, 3.5 mmol) was dissolved in tetrahydrofuran (THF, 75 ml), Bromine (1.5 ml, 3.5 mmol) in THF (5 mL) was added dropwise. The resulting mixture was stirred at room temperature for overnight. 10% Sodium thiosulfate (5 ml) was added and the solution was basified using conc. aqueous NH4OH, and then extracted twice with chloroform. The organic layer was recrystallized from chloroform to give the product 5-bromo-8-methoxypsoralen (0.75 g, 73.5% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06187572B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-fdf678b5afe04bf8a8b0eadfaf81ea50 |
| 出典メモ | uspto-grants-2001_02 |