3-Butenylbenzene → 2-(2-n-Propoxyphenyl)-8-(4-Phenyl-1-Buten-1-yl)Quinazolin-4(3H)-One

HRID 635198Notes

Reaction equation

HRID 635198 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[NH:20][C:19](=[O:21])[C:18]2[C:13](=[C:14](I)[CH:15]=[CH:16][CH:17]=2)[N:12]=1)[CH2:2][CH3:3].[C:23]1([CH2:29][CH2:30][CH:31]=[CH2:32])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[NH:20][C:19](=[O:21])[C:18]2[C:13](=[C:14]([CH:32]=[CH:31][CH2:30][CH2:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:15]=[CH:16][CH:17]=2)[N:12]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 130333-ButenylbenzeneHCID 1355493722-(2-n-Propoxyphenyl)-8-Iodoquinazolin-4(3H)-One

Product 1

HCID 1361516182-(2-n-Propoxyphenyl)-8-(4-Phenyl-1-Buten-1-yl)Quinazolin-4(3H)-OneYield 49.9%

Procedure

The title compound is prepared analogously to the method of Example 2, starting with the compound from Example III and 4-phenyl-1-butene.

Sources & evidence

ORD record
ord-2f3c50287da4411588f296aaf6c4a7a8
Source dataset
uspto-grants-2001_02
Patent number
US06187779B1

Reaction notes

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