HRID635204

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID519421

1-Phenyl-3-pentene

C11H14

结构：CCCOc1ccc(S(=O)(=O)N2CCOCC2)cc1-c1nc2c(Br)cccc2c(=O)[nH]1

HCID136186409

未命名化合物

PRODUCTS

生成物

结构：CCCOc1ccc(S(=O)(=O)N2CCOCC2)cc1-c1nc2c(C(=CCc3ccccc3)CC)cccc2c(=O)[nH]1

HCID136160088

未命名化合物

收率 39%

PROCEDURE

实验过程

The title compounds are prepared analogously to the method of Example 1, starting with 2-(2-n-propoxy-5-morpholinosulfonylphenyl)-8-bromoquinazolin-4(3H)-one and 5-phenyl-2-pentene, respectively.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-50226642bad14d769d46daa2f7bf9359
来源数据集: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06187779B1
来源说明: uspto-grants-2001_02

反应 SMILES

[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:6]=1[C:20]1[NH:29][C:28](=[O:30])[C:27]2[C:22](=[C:23](Br)[CH:24]=[CH:25][CH:26]=2)[N:21]=1)[CH2:2][CH3:3].[C:32]1([CH2:38][CH2:39][CH:40]=[CH:41][CH3:42])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:6]=1[C:20]1[NH:29][C:28](=[O:30])[C:27]2[C:22](=[C:23]([C:40](=[CH:39][CH2:38][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:41][CH3:42])[CH:24]=[CH:25][CH:26]=2)[N:21]=1)[CH2:2][CH3:3]