Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 1526910 | HCID 1526910 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 11023831 | HCID 11023831 | 95% |
Reaction Steps
300 g of 6-amino-1(p-methoxybenzyl)-uracil are taken up in 1200 ml of methanol and mixed with 105 g of NaHCO3. After cooling to 5° C., 66 ml of bromine are added dropwise with stirring. After the conversion is complete (about 2 hours) the resulting suspension is suction filtered, the residue is washed with methanol (2×100 ml) and the product is isolated in the form of bright yellow crystals (374 g, 95%) (melting point: 247° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06187780B1 |
|---|
| Source dataset | uspto-grants-2001_02 |
|---|
| ORD ID | ord-f330141acad740aa9f3852b1bd156cb3 |
|---|
| Source note | uspto-grants-2001_02 |
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