HCID 9964396, compound → N-Decylprop-2-enimidic acid
Reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:15])[CH:13]=[CH2:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(CCCCCCCCCCNC(=O)C=C)C=CC=CC=1.C(NC(=O)C=C)CC1C=CC=CC=1>>[CH2:10]([NH:11][C:12](=[O:15])[CH:13]=[CH2:14])[CH2:9][CH2:8][CH2:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]Participants
4
Procedure
The same procedure as in Example 18 was repeated except that N-(4-phenylbutyl)acrylamide, N-(10-phenyldecyl)acrylamide and N-phenethylacrylamide were used, respectively, in place of N-decylacrylamide to obtain N-cyclopropylmethyl-7α-(4-phenylbutylcarbamoyl)-6,14-endoethenotetrahydronormorphide 25.methanesulfonic acid salt (39%), N-cyclopropylmethyl-7β-(4-phenylbutylcarbamoyl)-6,14-endoethenotetrahydronormorphide 26.methanesulfonic acid salt (5%), N-cyclopropylmethyl-7α-(10-phenyldecylcarbamoyl)-6,14-endoethenotetrahydronormorphide 27.methanesulfonic acid salt (21%), and N-cyclopropylmethyl-7β-phenethylcarbamoyl-6,14-endoethenotetrahydronormorphide 28.methanesulfonic acid salt (3%), respectively.
Sources & evidence
- ORD record
- ord-5aae70bdb4d24318b7dee0fc637ff2fa
- Source dataset
- uspto-grants-2001_02
- Patent number
- US06187782B1
Reaction notes
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