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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 635209Generated: October 30, 2026

Benzenepropanoic acid → Benzenepentanoic acid

https://huagongshe.com/reaction/635209

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzenepropanoic acidHCID 107—
Reactant(1,1'-Biphenyl)-4-carboxylic acidHCID 66724—
Reactant5-Phenyl-2,4-pentadienoic acidHCID 73777—
ProductBenzenepentanoic acidHCID 16757—

Reaction Steps

The same procedure as in Example 31 was repeated except that 4-phenylbenzoic acid, 5-phenyl-2,4-pentadienoic acid and 3-phenylpropionic acid were used, respectively, in place of 5-phenylvaleric acid to obtain N-cyclopropylmethyl-7α-(4-phenylbenzoylamino)-6,14-endoethenotetrahydronorthebaine 41 (88%), N-cyclopropylmethyl-7α-(5-phenyl-2,4-bentadienoylamino)-6,14-endoethenotetrahydronorthebaine 42 (94%) and N-cyclopropylmethyl-7α-(3-phenylpropionylamino)-6,14-endoethenotetrahydronorthebaine 43 (84%), respectively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06187782B1
Source datasetuspto-grants-2001_02
ORD IDord-0ab55340b4d249b7918210331825aa65
Source noteuspto-grants-2001_02