Trifluoroacetic acid → HCID 23513749, compound

Participants

Reaction Steps

A mixture of the compound of Example 19 (45 mg), trifluoroacetic acid (1.0 mL) and trifluoromethanesulforic acid (1 mL) was refluxed for 8 hrs., and then condensed. The residue was dissolved in AcOEt (50 ml). The resulting solution was washed with 1 N NaOH solution, aqueous NH4Cl solution and brine, dried over Na2SO4. Removal of solvents gave a crude product, which was purified by silica gel column eluting with NH4OH (1N)—MeOH—CH2Cl2 (2.5:17.5:80) to provide N,N-diethyl-4-(8-quinolinyl-piperidin-4-ylidene-methyl)-benzamide (29 mg, 84%):

Provenance & Evidence