Cycloheptanone Oxime → HCID 59939442, compound

HRID 635285Notes

Reaction equation

HRID 635285 reaction equation
[C:1]1(=[N:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][C:27](OCC)=O)[CH2:20][CH2:19]2)[CH:14]=[CH:15][C:16]=1[F:17]>>[Cl:10][C:11]1[CH:12]=[C:13]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][C:27]3[O:9][N:8]=[C:1]4[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]=34)[CH2:20][CH2:19]2)[CH:14]=[CH:15][C:16]=1[F:17]

Participants

3

Reactant 2

HCID 137457Cycloheptanone OximeHCID 17773266HCID 17773266, compound

Product 1

HCID 59939442HCID 59939442, compound

Procedure

By the same reaction and treatment as in Example 48 using cycloheptanone oxime and ethyl 4-(4-(3-chloro-4-fluorophenyl)piperidin-1-yl)-n-butyrate, 3-(3-(4-(3-chloro-4-fluorophenyl)piperidin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole is obtained.

Sources & evidence

ORD record
ord-5c082b1272a941b2910973f728cb9b6a
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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