1-(p-Tolyl)piperazine → HCID 17773072, compound

HRID 635317Notes

Reaction equation

HRID 635317 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[N:14]1[NH:15][C:16]([CH2:23][CH2:24][C:25](O)=O)=[C:17]2[C:22]=1[CH2:21][CH2:20][CH2:19][CH2:18]2.Cl[C:29]1C=CC(C2CCNCC2)=CC=1>>[CH3:29][N:15]1[C:16]([CH2:23][CH2:24][CH2:25][N:11]2[CH2:12][CH2:13][N:8]([C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)[CH2:9][CH2:10]2)=[C:17]2[C:22]([CH2:21][CH2:20][CH2:19][CH2:18]2)=[N:14]1

Participants

4

Reactant 3

HCID 831131-(p-Tolyl)piperazineHCID 12036134-(4-Chlorophenyl)piperidineHCID 1785253693-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid

Product 1

HCID 17773072HCID 17773072, compound

Procedure

In the same manner as in Example 102 except that 3-(4,5,6,7-tetrahydro-2-methyl-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 9 and 1-(4-methylphenyl)piperazine are used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 1 and 4-(4-chlorophenyl)piperidine, 4,5,6,7-tetrahydro-2-methyl-3-(3-(4-(4-methylphenyl)piperazin-1-yl)propyl)-2H-indazole is obtained.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-200c912486cf49e481e1055c7d2b14d5
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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