Methyl iodide → HCID 17773258, compound

Participants

Reaction Steps

3-(3-(4-(4-Chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydroindole (0.5 g) obtained in Example 161 and potassium carbonate (0.6 g) were dissolved in dimethylformamide (10 ml) and methyl iodide (0.3 g) was added under ice-cooling with stirring. The reaction mixture was stirred at room temperature for 2 hours and the solvent was evaporated under reduced pressure. Chloroform and an aqueous potassium carbonate solution were added and the chloroform layer was separated. The layer was dried over magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography to give 3-(3-(4-(4-chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-1-methylindole.

Provenance & Evidence