HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Fluorophenyl)piperazine → 4-(4-Fluorophenyl)-1-(4-oxo-4-(2-oxocyclohexyl)butyryl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| Reactant | 4-(4-Chlorophenyl)piperidine | HCID 1203613 | — |
| Reactant | 4-Oxo-4-(2-oxocyclohexyl)butyric acid | HCID 3629131 | — |
| Reactant | 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid | HCID 178525369 | — |
| Product | 4-(4-Fluorophenyl)-1-(4-oxo-4-(2-oxocyclohexyl)butyryl)piperazine | HCID 17773198 | 102.8% |
Reaction Steps
4-Oxo-4-(2-oxocyclohexyl)-n-butyric acid (4.0 g) and 1-(4-fluorophenyl)piperazine (3.6 g) were used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Example 102 and 4-(4-chlorophenyl)piperidine, 7.4 g of 4-(4-fluorophenyl)-1-(4-oxo-4-(2-oxocyclohexyl)butyryl)piperazine was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06187774B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-bf5d8bbd0f2e4a1885b247511a15559c |
| Source note | uspto-grants-2001_02 |