Hydrogen Peroxide → HCID 178527114, compound

Participants

Reaction Steps

3-(3-(4-(4-Fluorophenyl)piperazin-1-yl)propyl)-2,4,6,7-tetrahydro-thiopyrano[4,3-c]pyrazole (0.5 g) obtained in Example 138 was dissolved in formic acid (5 ml) and 30% hydrogen peroxide (0.27 ml) was dropwise added under ice-cooling, and the mixture was stirred for 30 minutes at not more than 5° C. The reaction mixture was poured into ice water, made alkaline with potassium carbonate and extracted with ethyl acetate. After drying over magnesium sulfate, the solution was concentrated and recrystallized from isopropyl alcohol:isopropyl ether (1:2) to give 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-2,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole 5-oxide, m.p. 140-142° C.

Provenance & Evidence