Diethyl Ether → 1-[1-(4-Chlorophenyl)cyclobutyl]ethanone

A solution of 1-(4-chlorophenyl)cyclobutanecarbonitrile (238 g) in ether (500 ml) was added at reflux temperature under nitrogen over 40 minutes to stirred ethereal methylmagnesium iodide solution (3M; 701 ml). After the addition was complete, the mixture was stirred at reflux temperature for 3 hours and at ambient temperature for 60 hours. The resulting solid was collected by filtration, washed well with ether, and added in portions to a stirred mixture of crushed ice (1 l) and concentrated hydrochloric acid (1 l). The resulting mixture was stirred at 95° C. for 1 hour then cooled to ambient temperature. The product was extracted into dichloromethane (3×250 ml), and the combined extracts were washed with water (3×200 ml), dried (MgSO4), and the solvent was removed in vacuo. The residue was distilled to give 1-[1-(4-chlorophenyl)cyclobutyl]ethanone as a brown oil (198.1 g), b.p. 95-100° C. at 0.3 mbar.

1. temperatureat reflux temperature under nitrogen over 40 minutes
2. additionAfter the addition
3. temperatureat reflux temperature for 3 hours
4. filtrationThe resulting solid was collected by filtration
5. washwashed well with ether
6. additionadded in portions to a stirred mixture of crushed ice (1 l) and concentrated hydrochloric acid (1 l)
7. stirringThe resulting mixture was stirred at 95° C. for 1 hour
8. extractionThe product was extracted into dichloromethane (3×250 ml)
9. washthe combined extracts were washed with water (3×200 ml)
10. dry with materialdried (MgSO4)
11. customthe solvent was removed in vacuo
12. distillationThe residue was distilled

ORD record

ord-0efeb38078f04c638c5cbd18f385ee1c

Source dataset

uspto-grants-2001_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06187802B1