HCID 21258525, compound → 3-[1-(3,4-dichlorophenyl)cyclobutyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine hydrobromide

HRID 635346Notes

Reaction equation

HRID 635346 reaction equation
[BrH:1].[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2([C:14](=O)[CH2:15][S:16][C:17]3[NH:22][CH2:21][CH2:20][CH2:19][N:18]=3)[CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:7][C:8]=1[Cl:9]>C(O)(=O)C>[BrH:1].[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2([C:14]3[N:22]4[CH2:21][CH2:20][CH2:19][N:18]=[C:17]4[S:16][CH:15]=3)[CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:7][C:8]=1[Cl:9]

Participants

3

Reactant 1

HCID 21258525HCID 21258525, compound

Product 1

HCID 212584653-[1-(3,4-dichlorophenyl)cyclobutyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A suspension of 1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide (2.0 g—prepared in a manner similar to that described above) in acetic acid (7 ml) was heated under reflux for 16 hours, then allowed to cool to ambient temperature. The solvent was removed in vacuo, the residue was triturated with ether (50 ml), and the resulting solid was collected by filtration, washed with ether (50 ml), and dried in vacuo at ambient temperature to give 3-[1-(3,4-dichlorophenyl)cyclobutyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine hydrobromide as a white solid (1.7 g), m.p. 269° C.

Workup

  1. customprepared in a manner similar to
  2. temperaturewas heated
  3. temperatureunder reflux for 16 hours
  4. customThe solvent was removed in vacuo
  5. customthe residue was triturated with ether (50 ml)
  6. filtrationthe resulting solid was collected by filtration
  7. washwashed with ether (50 ml)
  8. customdried in vacuo at ambient temperature

Sources & evidence

ORD record
ord-ce2e6867b5c44f34a3ad635e90430b66
Source dataset
uspto-grants-2001_02
Patent number
US06187802B1

Reaction notes

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