反应详情

A mixture of 2-bromo-1-[1-(3,4-dichlorophenyl)cyclopentyl]ethanone (0.5 g), imidazolidine-2-thione (0.16 g), ethanol (3 ml) and acetic acid (2 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The solvents were removed in vacuo and the residue crystallised from a 1:1 mixture of ethyl acetate and ethanol. The resulting product was collected by filtration, washed with ethanol (3 ml) and dried in vacuo at 60° C. to give 3-[1-(3,4-dichlorophenyl)cyclopentyl]-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide as white microneedles (0.27 g), m.p. 230-232° C.

1. temperaturewas heated
2. temperatureunder reflux for 18 hours
3. customThe solvents were removed in vacuo
4. customthe residue crystallised from a 1:1 mixture of ethyl acetate and ethanol
5. filtrationThe resulting product was collected by filtration
6. washwashed with ethanol (3 ml)
7. customdried in vacuo at 60° C.