Ethanol → HCID 21258397, compound

Participants

Reaction Steps

A mixture of the crude 2-bromo-1-[1-(3,4-dichlorophenyl)cyclobutyl]-4-methoxybutan-1-one described above, imidazolidine-2-thione (0.68 g), ethanol (15 ml) and acetic acid (10 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The solvents were removed in vacua and the residue was dried by azeotropic distillation with ethanol (50 ml) followed by ethyl acetate (20 ml). The solid remaining after removal of residual solvent in vacuo was crystallised from a 2:1 mixture of ethanol and ethyl acetate. The resulting product was collected by filtration, washed with ethanol (10 ml) and dried in vacuo at 60°0 C. to give 3-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(2-methoxyethyl)-5,6-dihydroimidazo[2,1-b]-thiazole hydrobromide as colourless prisms (1.39 g), m.p. 227-229° C.

Provenance & Evidence