Ethanol → HCID 21258456, compound

Participants

Reaction Steps

A mixture of 2-bromo-1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-phenylethanone (3.8 g), imidazolidine-2-thione (0.97 g), ethanol (70 ml) and acetic acid (40 ml) was heated under reflux for 20 hours then allowed to cool to ambient temperature. The solvents were removed in vacuo and the residue was crystallised from ethanol. The resulting product was collected by filtration, washed with ethanol (10 ml) and dried in vacuo at 100° C. to give 3-[1-(3,4-dichlorophenyl)cyclobutyl]-2-phenyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide as a pale brown solid (1.43 g), m.p. 280° C. (decomposes).

Provenance & Evidence