Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 635431Notes

Reaction equation

HRID 635431 reaction equation
[OH:1]N1C(=O)CCC1=O.[CH2:9]1[CH2:14][CH2:13][CH:12]([N:15]=[C:16]=[N:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[CH2:11][CH2:10]1>C(#N)C>[C:16]([NH:15][CH:12]1[CH2:11][CH2:10][CH2:9][CH2:14][CH2:13]1)([NH:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)=[O:1]

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 80170N-Hydroxysuccinimide

Product 1

HCID 4277N,N'-Dicyclohexylurea

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Ligand A (150 mg; 0.4 mmol), N-hydroxysuccinimide (60 mg; 0.522 mmol) and DCC (101 mg; 0.49 mmol) were stirred in 4 ml of acetonitrile at room temperature for 2 hours. Dicyclohexylurea formed was removed by filtration and rinsed with about I ml of acetonitrile.

Sources & evidence

ORD record
ord-31513aedae4a4a2da8d1483348ee4925
Source dataset
uspto-grants-2001_02
Patent number
US06187907B1

Reaction notes

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