HCID 22618714, compound → HCID 22618819, compound

HRID 635470Notes

Reaction equation

HRID 635470 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][C:17]1([CH3:23])[CH2:21][O:20][C:19](=[O:22])[NH:18]1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][C:17]1([CH3:23])[CH2:21][O:20][C:19](=[O:22])[NH:18]1

Participants

4

Reactant 1

HCID 22618714HCID 22618714, compound

Product 1

HCID 22618819HCID 22618819, compoundYield 61.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of 4-(2-(2-benzyloxyphenyl)ethyl)-4-methyl-2-oxazolidinone (4.60 g) in ethanol (200 ml), 10% palladium-carbon (0.60 g) was added and the mixture was subjected to catalytic reduction at room temperature for 6 hours. Catalyst was filtered off form the reaction solution and the solvent was distilled away under reduced pressure. The residue was crystallized from ether-isopropyl ether to give the subject compound (2.0 g).

Workup

  1. filtrationCatalyst was filtered off
  2. customform the reaction solution
  3. distillationthe solvent was distilled away under reduced pressure
  4. customThe residue was crystallized from ether-isopropyl ether

Sources & evidence

ORD record
ord-ad3dd427abd447d2a1d294f6c20776f5
Source dataset
uspto-grants-2001_02
Patent number
US06187821B1

Reaction notes

Loading…