HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzoyl chloride → HCID 136187746, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| Reactant | 2′-Deoxy-N-(2-phenoxyacetyl)guanosine | HCID 135529932 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 136187746 | HCID 136187746 | — |
Reaction Steps
The synthesis of this product is carried out by reacting 1.1 eq of p-nitrobenzoyl chloride with 2-N-phenoxyacetyldeoxyguanosine for 16 hours in pyridine. After extraction with a dichloromethane/sodium bicarbonate mixture and evaporation to dryness, the product is taken up in chloroform and purified on a silica column (elution 4% methanol). The product is only slightly soluble in organic solvents.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06187914B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-8e38cd4cc07e49aa8bbe3516d4e4477d |
| Source note | uspto-grants-2001_02 |