HCID 15518231, compound → HCID 11721210, compound

Participants

Reaction Conditions

Reaction Steps

After 2,3-(methylenedioxy)-5-methyl-6-[3-(t-butyldimethylsiloxy)propyl]-7-benzyloxy-8-methoxy-5, 6-dihydrobenzo[c]phenanthridine (871 mg, 1.46 mmol) was dissolved in toluene (30 mL), activated manganese dioxide (4.36 g) was added to the solution. The mixture was stirred at 100° C. for 2 hours. Manganese dioxide was removed by filtration. Thereafter, the filtrate was concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (eluted with 33-66% methylene chloride-hexane) to provide 2,3-(methylenedioxy)-6-[3-(t-butyldimethylsiloxy)propyl]-7-benzyloxy-8-methoxy-benzo[c]phenanthridine (457 mg, yield 54%) as colorless powders.

Provenance & Evidence