HCID 15518232, compound → HCID 15518233, compound

Participants

Reaction Steps

After 2,3-(methylenedioxy)-5-methyl-6-[4-(t-butyldimethylsiloxy)butyl]-7-benzyloxy-8-methoxy-5,6-dihydrobenzo[c]phenanthridine (300 mg, 0.49 mmol) was dissolved in toluene (8 mL), activated manganese dioxide (1.5 g) was added to the solution. The mixture was heated to reflux for an hour. After cooling to room temperature, the reaction mixture was diluted with a 10% methanol-methylene chloride solution (12 mL) followed by filtration. The filtrate was concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (eluted with methylene chloride) to provide 2,3-(methylenedioxy)-6-[4-(t-butyldimethylsiloxy)butyl]-7-benzyloxy-8-methoxy-benzo[c]phenanthridine (205 mg, yield 70%) as light brown crystals.

Provenance & Evidence