HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Chloro-4-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3'-Chloro-4'-fluoroacetophenone | HCID 520422 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Reactant | Sodium hypobromite | HCID 23673712 | — |
| Product | 3-Chloro-4-fluorobenzoic acid | HCID 520989 | 74% |
Reaction Steps
The 3-chloro-4-fluoroacetophenone is then reacted with an aqueous solution of sodium hypobromite, the aqeuous phase is treated with sodium hydrogensulfite and acidified with hydrochloric acid, and the precipitated product is recrystallized from benzene. 3-Chloro-4-fluorobenzoic acid obtained in a yield of 74%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06187952B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-d546c0be93c5496da77831fb43df7de5 |
| Source note | uspto-grants-2001_02 |