Potassium Carbonate → HCID 178433170, compound

Participants

Reaction Steps

This compound was prepared according to the method described in Example 2, by employing 2-methyl-4-chloro-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine (Example 1(e)) (100 mg, 0.41 mmol), 2-phenoxyethylamine (Lancaster Synthesis Ltd.) (0.28 g, 2.05 mmol) and potassium carbonate (0.567 g, 4.1 mmol) in H2O (2.5 mL) to give 30.7 mg (22%) of the title compound as white crystals. MP: 266.9-267.4° C. (dec). 1H NMR (DMSO-d6; 400 MHz): δ 2.43 (s, 3), 3.91-3.93 (m, 2), 4.22 (t, 2, J=5.3), 6.74 (s, 1), 6.93-7.07 (m, 4), 7.29-7.40 (m, 3), 7.49-7.52 (m, 2), 7.79 (d, 2, J=7.79), 11.33 (br s, 1). MS m/z: 345 (M+1), 343 (M−1). Anal. Calcd for C19H24N4O: C, 70.34; H, 7.46; N, 17.27. Found: C, 70.14; H, 7.35; N, 17.13.

Provenance & Evidence