Piperidine → HCID 178488443, compound

Participants

Reaction Steps

Using the method described in Example 30 by employing 2-fluoro-1-methoxy-4-(1-pyrrolidinylvinyl) benzene (freshly prepared before use from 3-fluoro-4-methoxyacetophenone (Aldrich Chemical Company), pyrrolidine and TiCl4 (1.37 g, 6.19 mmol), 2-methyl-4,6-dichloro-5-nitropyrimidine (Example 76(b)) (1.30 g, 6.19 mmol), N,N-diisopropylethylamine (1.1 mL, 6.19 mmol), piperidine (1.0 mL, 9.9 mmol), NEt3 (1.1 mL) and SnCl2 (19 mL of a 2 M soln in DMF). In this example the 2 M SnCl2 solution was added to the reaction mixture at 140° C. Heating was then discontinued and the mixture was allowed to cool to room temperature. The mixture was stirred at room temperature for an additional 48 h. The residue was purified by flash chromatography on silica gel with 95:5 CHCl3/MeOH as eluant to give 481 mg (23%) of 2-fluoro-1-methoxy-4-[2-methyl-4-piperidylpyrrolo[4,5-d]pyrimidin-6-yl]benzene as a beige colored solid. This compound (481 mg, 1.41 mmol) was dissolved in 4:1 EtOAc/MeOH (30 mL) and heated to boiling. To the hot solution was added 1 M ethereal HCl (1.40 mL, 1.40 mmol). The solution was allowed to cool to room temperature. The resulting crystals were collected by filtration, washed with EtOAc (2×10 mL), Et2O (3×15 mL) and dried under vacuum at 60° C. to give 372 mg (16%) of the title compound as a beige colored solid. Mp: 262-264° C. 1H NMR (DMSO-d6; 500 MHz): δ 1.69 (br s, 6), 2.56 (s, 3), 3.92 (s, 3), 4.05 (br t, 4, J=5.4), 6.59 (s, 1), 7.33 (t, 1, J=8.8), 7.80 (d, 1, J=8.6), 7.96 (dd, 1, J=2.0, 12.7), 11.82 (s, 1), 14.20 (s, 1). MS m/z: 341 (M+1 for free base). Anal. Calcd for C19H21FN4O.HCl.0.5H2O: C, 59.08; H, 5.96; N, 14.51; Cl, 9.08. Found: C, 58.90; H, 5.89; N, 14.46; Cl, 9.30.

Provenance & Evidence