Piperidin-4-ol → HCID 178433079, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 173, using 4-hydroxy piperidine (Aldrich Chemical Company) (0.26 g, 2.57 mmol) and 2-methyl-4-chloro-6-phenylpyrrolo[3,2-d]pyrimidine (Example 1e) (0.49 g, 2.0 mmol), as a white solid (0.30 g, 48%). 1H NMR (DMSO-d6; 400 MHz) d 1.51-1.59 (m, 2), 2.58 (s, 3), 3.78-3.90 (m, 3), 4.34-4.37 (m, 2), 6.89 (s, 1), 7.49-7.57 (m, 3), 7.96 (d, 2, J=7.2), 11.8 (br s, 1). MS m/z: 308 (M+1). Anal. Calcd for C18H20N4O.HCl.0.33H2O: C, 61.62; H, 5.94; N, 15.97; Cl, 10.10. Found: C, 61.62; H, 5.91; N, 15.81; Cl, 10.28.

Provenance & Evidence