5-Aminopentan-1-ol → HCID 178433156, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 173, using 5-amino-1-pentanol (Fluka Chemika) (0.35 g, 3.4 mmol) and 2-methyl-4-chloro-6-phenylpyrrolo[3,2-d]pyrimidine (Example 1e) (0.42 g, 1.73 mmol), as a white solid (0.36 g, 61%). 1H NMR (DMSO-d6; 400 MHz): d 1.46 (br s, 4), 1.68 (bs, 2), 2.58 (s, 3), 3.62 (br s, 2), 4.40 (br s, 1), 6.93 (s, 1), 7.46-7.54 (m, 3), 8.05 (br, 2), 9.61 (s, 1), 13.47 (s, 1). MS m/z: 311 (M+1). Anal. Calcd for C18H22N4O.HCl.0.28H2O: C, 61.42; H, 6.75; N, 15.92; Cl, 10.07. Found: C, 61.42; H, 6.67; N, 15.75; Cl, 10.17.

Provenance & Evidence