Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2(3H)-Furanone, 3-bromodihydro- | HCID 95463 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 2768332 | HCID 2768332 | 40% |
Reaction Steps
2.18 g of 2-aminophenol and 1.1 equivalents of 2-bromo-γ-butyrolactone are mixed in 25 ml of DMF with 4 g of potassium carbonate. After 6 hours, it is heated to 75° C., poured onto water, extracted with ethyl acetate, the organic phase is dried with sodium sulfate and concentrated by evaporation. 40% yield results.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06191127B1 |
|---|
| Source dataset | uspto-grants-2001_02 |
|---|
| ORD ID | ord-10fffe9ef3254ce782ee3b3065bcecf6 |
|---|
| Source note | uspto-grants-2001_02 |
|---|
