HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Butyl-2-oxo-quinoline-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(n-Butyl)-4-(n-butyloxycarbonyl)-2-oxo-1,2-dihydro-quinoline | HCID 10447601 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Butyl-2-oxo-quinoline-4-carboxylic acid | HCID 285610 | 87% |
Reaction Steps
A mixture of 2.04 g (6.77 mmols) of Compound b, 0.54 g of sodium hydroxide, 40 ml of water and 40 mt of dioxane was stirred at room temperature for 30 minutes. After concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1) to give 1.44 g (yield: 87%) of Compound a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05248684 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-0b7ac1002a9c48df9ec7bd4af81498e1 |
| Source note | uspto-grants-1993_09 |