1-Benzylpiperazine → HCID 178521570, compound

HRID 635802Notes

Reaction equation

HRID 635802 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C@H:14]2[CH2:19][CH2:18][C@H:17]([OH:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C(N1CCNCC1)C1C=CC=CC=1.[BH4-].[Na+].[H][H]>C(O)C.[Pd]>[N:11]1([C@H:14]2[CH2:15][CH2:16][C@H:17]([OH:20])[CH2:18][CH2:19]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

7

Reactant 4

HCID 759941-BenzylpiperazineHCID 4311764Sodium borohydrideHCID 178418361HCID 178418361, compoundHCID 178521572HCID 178521572, compound

Product 1

HCID 178521570HCID 178521570, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

trans-4-(4-Benzylpiperazin-1-yl)cyclohexanol (prepared from benzylpiperazine according to the process described in Example 1 using, in Stage e, NaBH4 in ethanol) (15 g, 54.6 mmol) is placed in 150 ml of ethanol under 4 bar of hydrogen in the presence of 10% palladium-on-charcoal (1 g) . After stirring for 72 h, the catalyst is filtered off on celite and the filtrate is concentrated to dryness. 9.6 g of light-colored oil are isolated.

Workup

  1. filtrationthe catalyst is filtered off on celite
  2. concentrationthe filtrate is concentrated to dryness

Sources & evidence

ORD record
ord-ab39b63b24b14179b01d7621dc432b5c
Source dataset
uspto-grants-2001_02
Patent number
US06191130B1

Reaction notes

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