Pyrrolidine → HCID 69946308, compound

Participants

Reaction Steps

A 10 g (0.03 mole) sample of 4-chloro-1-[5-(4-chlorobenzoyl)-1-methyl-1H-pyrrol-3-yl]-butanone was added to 18 mL (0.216 mole) of pyrrolidine and the mixture heated under reflux for 4 h. The solvent was evaporated in vacuo and the residue triturated with Et2O. The mixture was filtered and the filtrate treated with ethereal HCl to give the salt. Recrystallization from CH3CN gave 1.18 g (9% yield) of a yellow solid: mp 203-206° C. 1H NMR (Me2SO-d6) d 1.85-2.05 (m, 10H); 2.87-3.05 (m, 4H); 3.1-3.15 (m, 2H); 3.3-3.4 (m, 4H); 3.45-3.55 (broad s, 2H); 3.9 (s, 3H); 6.62 (d, 2H); 6.96 (s,1H); 7.72 (d, 2H); 7.92 (s, 1H). Anal Calcd for C24H31N3O2-HCl-0.4CH3CN: C, 66.73; H, 7.50; N, 10.67. Found: C, 66.34; H, 7.43; N, 10,33.

Provenance & Evidence