HCID 15521023, compound → 2,3-Dimethylimidazo[2,1-b]thiazole-5-methanol

Participants

Reaction Steps

A solution of 2,3-Dimethylimidazo[2,1-b]thiazole-5-carboxylic acid ethyl ester (Formula A-4) (1.68 g) in THF (50 mL) at 0° was treated with LiAlH4 (0.38 g) and reacted at 25° for 1.5 hours. Excess reagent was quenched by sequential addition of water and 15% sodium hydroxide. The resulting mixture was diluted with THF (100 mL), filtered, and the filtrate was evaporated to a residue of crude 2,3-Dimethylimidazo[2,1-b]thiazole-5-methanol (Formula A-5) (1.04 g). Crystallization from isopropanol solution gave pure 2,3-Dimethylimidazo[2,1-b]thiazole-5-methanol (Formula A-5), m.p. 166-167°.

Provenance & Evidence