反应详情

A solution of (2-Phenylethyl)-3-methylimidazo[2,1-b]thiazol-5-yl methanone (Formula B-6) (0.40 g) in ethanol (5.0 mL) was treated with a solution of NaBH4 (0.05 g) in ethanol (5 mL) and reacted for 18 hours. The solvent was removed in vacuo and the residue was treated with 5% acetic acid solution. Precipitated 3-Methyl-α-(2-phenylethyl)imidazo[2,1-b]thiazole-5-methanol (Formula B-8) (0.38 g) was filtered and recrystallized from isopropanol solution to provide pure 3-Methyl-α-(2-phenylethyl)imidazo[2,1-b]thiazole-5-methanol (Formula B-8) (0.35 g), m.p. 144-145°.

1. customreacted for 18 hours
2. customThe solvent was removed in vacuo
3. additionthe residue was treated with 5% acetic acid solution
4. filtrationPrecipitated 3-Methyl-α-(2-phenylethyl)imidazo[2,1-b]thiazole-5-methanol (Formula B-8) (0.38 g) was filtered
5. customrecrystallized from isopropanol solution