Acetic Acid → HCID 54221264, compound

Participants

Reaction Steps

A suspension of 2-[[(Dimethylamino)methylene]amino]-3-(2-ethoxy-2-oxoethyl)-5,6-dihydro-4H-cyclopentathiazolium bromide (Formula E-3) (4.0 g) in DMF (20 mL) dissolved on addition of DBU (2.48 mL). The solution was reacted at 25° for 18 hours, poured into cold 10% acetic acid solution, and precipitated 6,7-Dihydro-5H-cyclopent[d]imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester (Formula E-4) (1.95 g) was filtered. Crystallization of an aliquot from isopropanol gave pure 6,7-Dihydro-5H-cyclopent[d]imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester (Formula E-4), m.p. 101-102°.

Provenance & Evidence