Aluminium lithium hydride → HCID 21256505, compound

Participants

Reaction Steps

A solution of 6,7-Dihydro-5H-cyclopent[d]imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester (Formula E-4) (5.8 g) in dry THF (125 mL) was treated with LiAlH4 (1.86 g) and reacted for 5.5 hours. After serial quenching with water and 15% sodium hydroxide, the suspension was diluted to 700 mL with chloroform. The filter cake was washed with hot chloroform, the combined filtrate and washes were evaporated to yield pure 6,7-Dihydro-5H-cyclopent[d]imidazo[2,1-b]thiazole-3-methanol (FIG. E-5) (2.67 g).

Provenance & Evidence