Aluminium lithium hydride → HCID 21256484, compound

Participants

Reaction Steps

A solution of 6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester (Formula G-4)(11.7 g) in THF (50 mL) was treated with LiAlH4 (2.24 g) at 0° and reacted at ambient temperature for 1.5 hours. The reaction was quenched by serial additions of water and 15% sodium hydroxide. The mixture was filtered and the filtrate was evaporated to yield crude 6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazole-3-methanol (Formula G-5). Crystallization of crude 6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazole-3-methanol (Formula G-5) from iso-propanol solution gave pure 6,7,8,9-Tetrahydro-5H-cyclohept [d]imidazo[2,1-b]thiazole-3-methanol (Formula G-5) (7.7 g) m.p. 145-146°.

Provenance & Evidence