HCID 21256459, compound → HCID 21256498, compound

Participants

Reaction Steps

A solution of 5,6,7,8,9,10-Hexahydrocyclooct[d]imidazo[2,1-b]thiazole-3-methanol (Formula H-5) (1.6 g) in hot toluene (250 mL) was treated with MnO2 (3.8 g) and azeotropically distilled for 1 hour. The cooled mixture was filtered and the combined filtrate and ethyl acetate washes were evaporated to yield pure 5,6,7,8,9,10-Hexahydro-cyclooct[d]imidazo[2,1-b]thiazole-3-carboxaldehyde (Formula H-6) (1.41 g), m.p. 106-107°, after crystallization from hexane.

Provenance & Evidence