HCID 21256500, compound → HCID 21256457, compound

Participants

Reaction Steps

A solution of 7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol (Formula L-2) (1.0 g) in DMF (5 mL) was diluted with toluene (200 mL), the warm solution was treated with activated MnO2 (2.34 g) and azeotropically distilled for 4 hours. The cooled suspension ws filtered, the filtrate was concentrated in vacuo and the residue was diluted with ice water. Precipitated 7-Fluoro-imidazo [2,1-b]benzothiazole-3-carboxaldehyde (Formula L-3) was filtered and recrystallized from acetonitrile to yield pure 7-Fluoro-imidazo[2,1-b]benzothiazole-3-carboxaldehyde (Formula L-3) (0.89 g), m.p. 182-183°.

Provenance & Evidence