2,3-Difluorobenzaldehyde → HCID 70057032, compound

HRID 635876Notes

Reaction equation

HRID 635876 reaction equation
[N:1]1[CH:2]=[C:3]([C:14](=[O:16])[CH3:15])[N:4]2[C:8]3[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:7]=3[S:6][C:5]=12.[F:17][C:18]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:19]=1[CH:20]=O>>[F:17][C:18]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:19]=1[CH:20]=[CH:15][C:14]([C:3]1[N:4]2[C:5]([S:6][C:7]3[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]=32)=[N:1][CH:2]=1)=[O:16]

Participants

3

Reactant 2

HCID 1376642,3-DifluorobenzaldehydeHCID 212564561-(6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-ethanone

Product 1

HCID 70057032HCID 70057032, compound

Procedure

1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)ethanone (Formula N-4), 1.87 g and 2,3-difluorobenzaldehyde (1.39 g) were condensed by non-critical variations in PREPARATION 15 to provide 3-(2,3-Difluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one (Formula N-5, X=2,3-difluoro), 1.35 g, m.p. 193-195°.

Workup

  1. customcondensed by non-critical variations
  2. customin PREPARATION 15

Sources & evidence

ORD record
ord-74705f1317b342b3bacae096c492d904
Source dataset
uspto-grants-2001_02
Patent number
US06191124B1

Reaction notes

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