Sodium borohydride → HCID 467124, compound

HRID 635879Notes

Reaction equation

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][C:13]([C:15]1[N:22]2[C:18]([S:19][C:20]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][C:21]=32)=[N:17][CH:16]=1)=[O:14].[BH4-].[Na+]>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][CH:13]([C:15]1[N:22]2[C:18]([S:19][C:20]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][C:21]=32)=[N:17][CH:16]=1)[OH:14]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 21256437HCID 21256437, compound

Product 1

HCID 467124HCID 467124, compound

Procedure

3-(2-Napthalenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-1-propanone (Formula O-3), 0.10 g, was reduced with NaBH4 by non-critical variations of EXAMPLE 12 to yield pure α-[2-(2- Naphthalenyl)ethyl]-6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-methanol (Formula O-4, X=H), m.p. 124-127°.

Sources & evidence

ORD record: ord-c3cfe9cee31f4a33a46953567a4c6446
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06191124B1

Reaction notes

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