HCID 131722394, compound → HCID 15338726, compound

Participants

Reaction Steps

35.2 g (0.15 mol) of 6-carboxy-2,2-dimethyl-4-chromanone oxime are dissolved in 300 ml of methanol by addition of 600 ml of concentrated aqueous ammonia and, after addition of a few grams of Raney nickel catalyst, hydrogenated at 80° C. for 10 hours under 100 atm hydrogen pressure. After filtering off the catalyst, approximately ¾ of the solvent is distilled off in a rotary evaporator. The crystalline precipitate of 4-amino-6-carboxy-2,2-dimethylchroman is filtered off.

Provenance & Evidence