5-Amino-2-methoxyphenol → 1-[(3-Hydroxy-4-methoxyphenyl)aminosulfonyl]-2,3,4-trimethoxybenzene

HRID 635997Notes

Reaction equation

HRID 635997 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[S:13](Cl)(=[O:15])=[O:14].[OH:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[NH2:21]>CO>[OH:17][C:18]1[CH:19]=[C:20]([NH:21][S:13]([C:4]2[CH:5]=[CH:6][C:7]([O:11][CH3:12])=[C:8]([O:9][CH3:10])[C:3]=2[O:2][CH3:1])(=[O:15])=[O:14])[CH:22]=[CH:23][C:24]=1[O:25][CH3:26]

Participants

4

Reactant 2

HCID 743145-Amino-2-methoxyphenolHCID 47127422,3,4-trimethoxybenzenesulfonyl Chloride

Product 1

HCID 98422601-[(3-Hydroxy-4-methoxyphenyl)aminosulfonyl]-2,3,4-trimethoxybenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2,3,4-trimethoxybenzenesulfonyl chloride (500 mg, 1.88 mmol) in methanol (mL) is added 3-hydroxy-4-methoxyaniline (523 mg, 3.76 mmol) at ambient temperature. The reaction is stirred for 1 h, the solvent is then evaporated and the crude product is purified by flash chromatography over silica.

Workup

  1. customthe solvent is then evaporated
  2. customthe crude product is purified by flash chromatography over silica

Sources & evidence

ORD record
ord-3f8cbb7449f743598eca5b6279523184
Source dataset
uspto-grants-2001_02
Patent number
US06191170B1

Reaction notes

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