反应详情

To a solution of 3-phenyl-5-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine (113 mg, 0.38 mmol) in CH2Cl2 (325 μl) is added BBr3 (1.1 ml of 1 N solution in CH2Cl2, 1.13 mmol). The reaction mixture is stirred for 15 hours at room temperature and neutralized at 0° C. with methanol. The solvent is evaporated under reduced pressure and the residue purified by preparative thin-layer chromatography (CH2Cl2/MeOH 94:6) to yield the expected product in the form of a white solid with a yield of 34%.

1. customThe solvent is evaporated under reduced pressure
2. customthe residue purified by preparative thin-layer chromatography (CH2Cl2/MeOH 94:6)