Hydrochloric Acid → HCID 86756432, compound

Participants

Reaction Steps

(2S)-2-tert-Butoxycarbonylamino-5-(nitroimino-amino)methylaminopentanoic acid 1,3-thiazol-2-ylamide (2.28 g, 5.68 mmol) is dissolved in 5 mL THF and 5 mL 4 N HCl in dioxane. After 3 h, dichloromethane is added and the mixture is filtered. The semisolid is collected and is treated with methanol—toluene and concentrated in vacuo; this process is repeated several times to afford 1.63 g of (2S)-2-amino-5-(nitroimino-amino)methylaminopentanoic acid 1,3-thiazol-2-ylamide hydrochloride as a solid.

Provenance & Evidence