HCID 86756434, compound → HCID 86756435, compound

Participants

Reaction Conditions

Reaction Steps

(2R,3S)-3-(Formyl-2-tetrahydropyranyloxyamino)-2-(2-methyl-1-propyl)hexanoic acid [(1S)-4-(nitroimino-amino)methylamino-1-(1,3-thiazol-2-ylcarbamoyl)-1-butyl]amide (166 mg) is dissolved in 2 mL 80% acetic acid and heated at 40° C. for 20 h. Concentration in vacuo and trituration in dichloromethane—ether provides (2R,3S)-3-(formyl-hydroxyamino)-2-(2-methyl-1-propyl)hexanoic acid [(1S)-4-(nitroimino-amino)methylamino-1-(1,3-thiazol-2-ylcarbamoyl)-1-butyl]amide as a solid (106 mg, 74%).

Provenance & Evidence