HCID 54345618, compound → HCID 11128482, compound

Participants

Reaction Steps

Methyl (2R,3R)-2-benzyl-3-hydroxyhexanoate (3.35 g, 14.2 mmol) is dissolved in 35 mL of MeOH. Under an argon atmosphere 1.00 g of 5% rhodium on carbon is added. The reaction vessel is evacuated and refilled with hydrogen several times and then pressurized with hydrogen to 65 psi. After 8 h the reaction vessel is evacuated and refilled with nitrogen. The solution is filtered and the filtrate concentrated in vacuo giving methyl (2R,3R)-2-cyclohexylmethyl-3-hydroxyhexanoate as an oil (3.44 g, 99% yield).

Provenance & Evidence