HCID 86756437, compound → HCID 86756436, compound

Participants

Reaction Conditions

Reaction Steps

(2R,3S)-3-(Formyl-2-tetrahydropyranyloxyamino)-2-(cyclohexylmethyl)hexanoic acid [(1S)-4-(nitroimino-amino)methylamino-1-(1,3-thiazol-2-ylcarbamoyl)-1-butyl]amide (115 mg, 0.180 mmol) is dissolved in 2 mL of 80% acetic acid and heated at 40° C. for 20 h. Concentration in vacuo and trituration with dichloromethane—ether provided 81 mg of (2R,3S)-3-(formyl-hydroxyamino)-2-(cyclohexylmethyl)hexanoic acid [(1S)-4-(nitroimino-amino)methylamino-1-(1,3-thiazol-2-ylcarbamoyl)-1-butyl]amide as a solid.

Provenance & Evidence