HCID 15083844, compound → HCID 53982593, compound

Participants

Reaction Steps

Methyl (2R,3R)-2-(2-methyl-2-propen-1-yl)-3-hydroxybutanoate (8.1 g, 47.1 mmol) in 85 mL of EtOAc is treated with 800 mg of 10% palladium on carbon and the mixture is evacuated and purged with nitrogen. The heterogeneous solution is stirred under 52 psi of hydrogen for 1.5 h. Filtration and concentration of the filtrate in vacuo affords 7.99 g (96%) of methyl (2R,3R)-2-(2-methyl-1-propyl)-3-hydroxybutanoate as an oil.

Provenance & Evidence