HCID 86756443, compound → HCID 86756444, compound

Participants

Reaction Conditions

Reaction Steps

(2R,3S)-3-(Formyl-tetrahydropyranyloxyamino)-2-(2-methyl-1-propyl)butanoic acid [(1S,2R)-2-methyl-4-(nitroimino-amino)methylamino-1-(1,3-thiazol-2-ylcarbamoyl)-1-butyl]amide (30 mg, 0.049 mmol) is dissolved in 2 mL of 80% acetic acid and heated at 40° C. for 20 h. Concentration in vacuo, trituration with dichloromethane/ether, and collection of the product provides 26 mg of (2R,3S)-3-(formyl-hydroxyamino)-2-(2-methyl-1-propyl)butanoic acid [(1S,2R)-2-methyl-4-(nitroimino-amino)methylamino-1-(1,3-thiazol-2-ylcarbamoyl)-1-butyl]amide as a solid.

Provenance & Evidence